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The Plague of Justinian
The first recorded plague outbreak in the world. This sore appeared in 541 in Byzantium and claimed about 100 million lives. To understand the breadth of the problem, it is worth mentioning that the entire population of the then world did not exceed 400-450 million. The whole of Europe experienced the consequences of the plague, but the Byzantine Empire suffered the greatest losses, which soon fell, not fully recovering from the consequences.